Uninterested is the opposite of interested. It simply means you have no interest in something:
He's totally uninterested in traveling. He likes where he lives and never wants to leave.
We approached the other company and proposed a partnership, but they were uninterested.
In casual spoken English, we tend to say "not interested" for the word uninterested.
The word disinterested means somebody is neutral. They have no bias (opinions that could unfairly influence their judgment). If two people are having an argument, they should present the case to a disinterested third party who can give a clear and fair evaluation of the situation.
However, some people do mistakenly use "disinterested" where "uninterested" would be more accurate.
Young William Bailey here went through many changes as a kid, not the least of which was his bear. He went through a stage in between these photos where he was the singer for the biggest rock band on the planet during which time he looked a bit cooler.