Wile E. is obviously intelligent, what with the elaborate plans and schemes that he hatches to capture the Road Runner. But the amount of time and energy he puts into his coveted prey, repeatedly, despite his failures, shows how much of a fanatic he is in this regard. These traits are manifestations of his possible Obsessive Compulsive Disorder. He could also be suffering from Anorexia Nervosa, evident from his skinny physique, and his elaborate method to prepare or capture his food. His obsession is with the Road Runner, while ignoring food from a ready source.